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  1. ; ; ; ( , Journal of machine learning research)
    Accepted Manuscript Full Text Available
  2. ; ; ; ( , International Conference on Machine Leanring)
    Accepted Manuscript Full Text Available
  3. ; ; ; ; ( , International Conference on Machine Learning)
    Accepted Manuscript Full Text Available
  4. ; ; ; ; ; ; ( , Proceedings of the forty-third annual meeting of the North American Chapter of the International Group for the Psychology of Mathematics Education)
    Accepted Manuscript Full Text Available
  5. ; ; ; ; ; ; ( , Proceedings of the forty-third annual meeting of the North American Chapter of the International Group for the Psychology of Mathematics Education)
    Accepted Manuscript Full Text Available
  6. ; ; ; ; ; ; ( , Proceedings of the forty-third annual meeting of the North American Chapter of the International Group for the Psychology of Mathematics Education)
    Accepted Manuscript Full Text Available
  7. ; ; ; ; ; ( , Proceedings of the Annual Conference on Research in Undergraduate Mathematics Education)
    null (Ed.)
    Accepted Manuscript Full Text Available
  8. ; ; ; ; ; ; ; ; ; ; et al ( , Nature Communications)
    Abstract

    Central nervous system ischemic injury features neuronal dysfunction, inflammation and breakdown of vascular integrity. Here we show that activation of endothelial caspase-9 after hypoxia-ischemia is a critical event in subsequent dysfunction of the blood-retina barrier, using a panel of interrelated ophthalmic in vivo imaging measures in a mouse model of retinal vein occlusion (RVO). Rapid nonapoptotic activation of caspase-9 and its downstream effector caspase-7 in endothelial cells promotes capillary ischemia and retinal neurodegeneration. Topical eye-drop delivery of a highly selective caspase-9 inhibitor provides morphological and functional retinal protection. Inducible endothelial-specific caspase-9 deletion phenocopies this protection, with attenuated retinal edema, reduced inflammation and preserved neuroretinal morphology and function following RVO. These results reveal a non-apoptotic function of endothelial caspase-9 which regulates blood-retina barrier integrity and neuronal survival, and identify caspase-9 as a therapeutic target in neurovascular disease.

     
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  9. ; ; ; ( , Physical Review B)
  10. ; ; ; ; ; ; ; ( , Physical Review B)